8 Best Windows Server Antivirus for Server Protection in 2025

Cyber threats have become a constant presence nowadays, lurking around every corner, and are ready to strike anytime.

Whether you own a large business or a small, data is something you cannot compromise with and blindly leave it open for the cyber attackers.

In the battle against cyber threats, your server is the front line. You must ensure it’s armored with the best protection available. Thus, we have rounded up the top Windows Server antivirus for your business.

Best Windows Server Antivirus Comparison

Antivirus	Best For	Key Features	Starts From
Quick Heal	SMB data protection	Real-time scan, USB & email security	₹959/year
Microsoft Defender	Microsoft users	Cloud AI, threat hunting, no install needed	₹170
Kaspersky	Enterprise environments	Ransomware shield, app control	On request
Webroot	Lightweight security	AI detection, fast install, cloud console	$150 (5 devices)
Avast Business	Hybrid work setups	SharePoint & email protection	₹1,599
Sophos Intercept X	Advanced threat defense	Anti-ransomware, deep learning, XDR	On request
SentinelOne	Hybrid cloud security	Rollback, AI engine, MITRE ATT&CK support	$179.99
ESET	Centralized management	Ransomware recovery, brute force defense	₹785

List of Trusted Windows Server Antivirus Software in 2025

1. Quick Heal AntiVirus for Server

Quick Heal is the first Windows server antivirus on the list. It offers a comprehensive security solution specifically for Windows Server environments.

It’s been reviewed positive by a numerous user for its strong protection against evolving cyber threats. It provides you the safety of critical data and uninterrupted server operations.

The tool includes specialized features to secure networks, emails, and external devices.

Quick Heal AntiVirus for Server

4.5

Starting Price

₹ 959.24 excl. GST

Key Features of Quick Heal:

Two-way firewall protection to monitor incoming and outgoing traffic
Full boot scan with customizable scheduling options
Hijack restore to revert browser settings altered by malware
Wi-Fi scanner to detect vulnerabilities in router security
USB drive protection against autorun malware infections
Real-time threat detection for immediate threat response
Behavioral analysis to catch suspicious patterns and activities
Anti-phishing and identity protection features
Rootkit detection and removal for deep system security
Email and web protection with URL filtering

Pros

Excellent customer support and a large knowledge base
User-friendly interface
Frequent real-time updates

Cons

Limited cloud-based features compared to competitors
A little issue with installation

Quick Heal Pricing: Its pricing starts at just INR 959/year at Techjockey.com.

2. Microsoft Defender for Endpoint

Microsoft Defender for Endpoint is a comprehensive antivirus software for windows server. It offers protection for a wide range of endpoints like servers, PCs, laptops, mobile devices. The solution supports Windows Server editions including 2012 R2 (with onboarding), 2016, 2019, 2022, and the upcoming 2025 version, and is available through Microsoft Defender for Servers Plan 1 or Plan 2.

Key Features of Microsoft Defender:

Detects suspicious activities using endpoint behavioral data
Analyzes threats with Microsoft’s cloud security AI
Uses expert threat intelligence to identify attacker methods
Manages vulnerabilities to assess and prioritize server risks
Applies protections and blocks harmful sites and IPs
Detects and investigates advanced attacks on endpoints
Automates threat investigation and response to reduce alerts
Assess security posture with Microsoft Secure Score
Supports centralized setup and API integrations
Integrates with Microsoft Defender, Sentinel, Intune, and more

Pros

Built into Windows, does not require additional installation
Strong cloud-based protection

Cons

Limited advanced features
May require additional configuration

Microsoft Defender Pricing: Starts at INR 170 via Techjockey.com.

3. Kaspersky for Windows Server

Kaspersky is a globally trusted Windows server antivirus solution. It is specifically built for Windows-based server environments in complex IT infrastructures. Designed to run efficiently under heavy load, it offers proactive threat detection, malware prevention, and real-time system integrity monitoring.

Key Features of Kaspersky:

Detects and blocks malware, ransomware, and zero-day threats using multilayered protection
Scans files in real-time or on demand with minimal impact on server performance
Quickly responds to new threats via the Kaspersky Security Network (KSN)
Prevents untrusted apps from running using Application Launch Control
Stops exploits targeting unpatched system vulnerabilities
Protects shared folders from ransomware with anti-Cryptor technology
Secures virtual machines, containers, and hybrid environments
Scans web and mail traffic to block phishing and malicious content

Pros

Strong, multi-layered security
Low performance impact
Supports virtual and container setups

Cons

Setup can be complex
Fine-tuning may be needed to avoid false blocks
Licensing costs can be high

Kaspersky Pricing: The pricing of Kaspersky for Windows server is available on request.

4. Webroot Server Antivirus Protection

Webroot Business Endpoint Protection is a lightweight, cloud-based antivirus solution. It helps to secure modern IT infrastructures, including Windows Server environments. It can be the ideal choice for businesses that require always-on security across physical servers, virtual environments, and endpoints.

Key Features of Webroot:

Protects against email, web, file, and app threats in real time
Uses AI and deep learning to improve detection
Blocks unknown threats using behavioral analysis
Offers 100% protection in 24 hours (MRG Effitas test)
Installs fast and runs with minimal system load
Works alongside existing antivirus software
Can restore infected files without reimaging
Supports remote management through a cloud console
Integrates with major RMM/PSA tools
Offers monthly or annual billing per device
Reduces system and admin overhead
Supports automation and reporting via API

Pros

Lightweight and fast
Strong AI-based threat detection
Easy to manage remotely with centralized online control

Cons

May require technical expertise to fully leverage API and integration features.

Webroot Pricing: It offers 1 year protection for five devices at $150.

5. Avast Business for Windows Servers and Data

Avast Business Antivirus simplifies server security management through an intuitive interface and cloud-based controls. It could be the perfect choice for businesses with remote or hybrid work models.

Key Features of Avast:

Protects SharePoint servers by scanning all uploaded files for malware
Provides Exchange Server protection by filtering malicious emails at the server level
Automates malware scanning to reduce manual security tasks
Adapts to modern cyber threats with advanced threat behavior analysis
Enables secure remote and collaborative work through cloud-based protection
Centralized device management via the Avast Business Hub platform
Lightweight and seamless installation on Windows Server environments
Ensures real-time scanning of server activity for maximum uptime and safety

Pros

Offers an easy-to-use interface
No system performance issues
Quick and non-disruptive installation

Cons

Scanning files during boot time is a little slower
Customer support is less responsive

Avast Pricing: Starts at INR 1,599.

6. Sophos Intercept X Advanced for Server

Sophos Server Workload Protection is a comprehensive security solution tailored for securing Windows Server environments—whether on-premises, in data centers, or in the cloud. It integrates next-gen antivirus capabilities, anti-ransomware tools, exploit prevention, deep learning-based threat detection, and centralized management via Sophos Central.

Sophos Intercept X for Server

4.6

Starting Price

Price on Request

Key Features of Sophos:

Uses AI-based deep learning to detect known and unknown malware
Prevents ransomware attacks and automatically recovers encrypted files using CryptoGuard
Stops attackers by blocking exploits commonly used in file-less and malware-less threats
Offers XDR for full visibility across servers, endpoints, and more
Locks down servers to run only approved applications
Sends alerts on critical file changes or tampering attempts
Centralized monitoring and policy management through the Sophos Central platform
Integrates with IT and DevOps tools using APIs for efficient operations

Pros

Advanced AI and deep learning
Easy deployment and centralized management
24/7 managed threat detection and response by experts

Cons

Advanced features may cost extra
Can impact performance on low-resource servers

Sophos Pricing: Pricing of Sophos is available on request.

7. SentinelOne – Windows Server Agent

SentinelOne provides advanced, AI-driven protection for Windows Server environments in hybrid cloud infrastructure. It helps secure modern enterprises running Windows Server across AWS, Azure, Google Cloud, and on-premises data centers.

SentinelOne

4.2

Starting Price

Price on Request

Key Features of SentinelOne:

Supports Windows Server versions from 2003 SP2 to 2019
Works on physical, virtual, and major cloud server environments
Real-time malware blocking with on-agent Static AI protection
Detects and stops unknown fileless threats using Behavioral AI
Enables fast disk scans directly on Windows Server endpoints
Centralized multi-tenant management from a unified web console
Enforces role-based access controls for granular server administration
Supports remote PowerShell for secure server-side investigation
One-click remediation and rollback for threat response on servers

Pros

Strong AI protection with no cloud delay
Easy rollback and remediation
Works across hybrid infrastructures

Cons

It may be complex for smaller teams
Limited support for very old systems
Requires agent installation on servers

SentinelOne Pricing: Starts at $179.99 on Techjockey.com.

8. ESET – Modern Endpoint Protection

ESET Endpoint Security is the last Windows Server antivirus on the list. It offers centralized management through a unified console, advanced ransomware defense, and safeguards against sophisticated attacks. The tool ensures continuous server security by detecting threats like fileless and brute force attacks.

Key Features of ESET:

Manage all Windows Server endpoints from a single unified console
Protect servers with advanced ransomware shield technology
Automatically restore files after ransomware attacks
Detect and block fileless attacks on Windows Servers
Secure web browsers used on Windows Server systems
Prevent brute force attacks targeting server logins

Pros

Centralized control simplifies server security management
Effective ransomware rollback minimizes data loss
Protects against advanced, stealthy fileless attacks

Cons

Ransomware remediation requires higher-tier subscriptions
May need IT expertise for optimal configuration
Some features focused more on endpoint than server specifics

ESET Pricing: Its pricing starts at INR 785 at Techjockey.com.

Conclusion

Cyber threats are not going to stop! It is you who has to take the sole responsibility to protect your business data from these attacks.

The above-mentioned all the antivirus software for windows server offer features for different business needs. These solutions ensure strong Windows Server virus protection without compromising the system’s performance.

It’s time to evaluate your server’s requirements and make a choice that aligns with your security goals.

The right security tool will completely take care of your entire Windows Server environment.